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Wednesday 12 June 2013

Premature menopause

Premature menopause

In rare cases, a woman's ovaries stop working at a very early age, from puberty to age 40, which is known as premature ovarian failure (POF). Spontaneous premature ovarian failure affects 1% of women age 40 and 0.1% of women 30 years of age. POF is not considered to be due to the normal effects of aging. Known causes of premature ovarian failure include autoimmune diseases, thyroid disease, diabetes mellitus, chemotherapy, as a gene carrier of fragile X syndrome and radiotherapy. However, in most cases spontaneous premature ovarian failure, the cause is unknown, ie it is generally idiopathic.

POF is diagnosed or confirmed by high blood levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in at least 3 times, at least 4 weeks apart. It has been found that the rates of premature menopause to be significantly higher in fraternal and identical twins, about 5% of twins reach menopause before age 40. The reasons for this are not fully understood. Ovarian tissue transplants between identical twins have been successful in restoring fertility.

1 comment:

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